There's a lot of humor to be mined from the idea of Hollywood coastal elites descending on a small town to make a movie, and in December of 2000, David Mamet's State and Main executed that formula flawlessly.
Whether your screenplay is written in three or five acts, an audience can only truly appreciate a complete story, so I say why not implement a proven form that has satisfied audiences for over two thousand years.
Barry Sonnenfeld's 'Get Shorty', which arrived in theaters 25 years ago last month, was one of the most purely entertaining studio comedies of the 1990s.